TOLWICK (Tablet)

TOLWICK is a high-potency tablet formulation containing Tolvaptan 15 mg.

Composition: Tolvaptan 15 mg
Dosage Form: Tablet

Clinical Pharmacology

Tolvaptan is a selective vasopressin V2-receptor antagonist. It promotes aquaresis by reducing vasopressin-mediated water reabsorption in the renal collecting ducts.

Indications & Usage

The indication depends on the approved therapeutic use and prescribing protocol and may include:

• Clinically significant hyponatremia associated with conditions such as heart failure, cirrhosis or SIADH, where approved
• Selected patients requiring vasopressin V2 receptor antagonism
• Other specialist indications according to the approved product information

Contraindications

Important contraindications include inability to respond to thirst, anuria, significant hypovolemia and hypersensitivity. Contraindications vary according to indication.

Warnings & Precautions

Tolvaptan can cause rapid correction of serum sodium and requires appropriate monitoring. Hepatic safety monitoring is important in indications involving prolonged therapy.

Drug Interactions

CYP3A4 inhibitors/inducers may significantly alter tolvaptan exposure. Monitor concurrent diuretics and medicines affecting sodium/water balance.

Pregnancy & Lactation

Avoid during pregnancy and breastfeeding unless specifically justified by a specialist.

Dosage & Administration

Initiation and dose titration should be performed according to the approved indication and appropriate monitoring protocol.

Adverse Reactions

Thirst, dry mouth, increased urination, hypernatremia, dizziness and dehydration.

Therapeutic Focus: Vasopressin Receptor Antagonist | Primary Specialty: Nephrology